Changes in Adipokine, Resitin, and BDNF Concentrations in Treatment-Resistant Depression after Electroconvulsive Therapy

Objectives: One of the current challenges in psychiatry is search for answers on how to effectively manage drug-resistant depression. The occurrence drug resistance patients an indication use electroconvulsive therapy (ECT). This method highly effective and usually results relatively quick health improvement. Despite knowledge ECT works, not all biological pathways activated during its have been identified. Hence, based neuroinflammatory hypothesis depression, we investigated concentration two opposite-acting adipokines (anti-inflammatory adiponectin proinflammatory resistin) BDNF antidepressant-resistant undergoing ECT. Methods: study group comprised 52 hospitalized due episodes depression course unipolar bipolar affective disorder. serum was determined before after therapeutic intervention using ELISA method. In analyses, also included comparisons considering type sex, achieving remission. Results: Adiponectin, resistin, concentrations change treatment. These changes are correlated with improvement severity depressive symptoms more or less pronounced depending Conclusions: Although observed reach statistical significance, particular remain exciting candidates biomarkers assessing disease response